P05067: Amyloid-beta precursor protein
Amyloid-beta precursor protein (APP) is a 770-residue protein from Homo sapiens. UniProt accession: P05067.
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By
Subcellular location
Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Early endosome, Early endosome, Secreted, Cell surface, Cell surface, Nucleus, Cytoplasm
Disease associations
Alzheimer disease 1 (AD1); Cerebral amyloid angiopathy, APP-related (CAA-APP)
Subunit structure
Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and, NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR
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