P31749: RAC-alpha serine/threonine-protein kinase
RAC-alpha serine/threonine-protein kinase (AKT1) is a 480-residue protein from Homo sapiens. UniProt accession: P31749.
Function
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960, PubMed:29343641, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most
Subcellular location
Cytoplasm, Nucleus, Cell membrane, Mitochondrion intermembrane space
Disease associations
Breast cancer (BC); Colorectal cancer (CRC); Proteus syndrome (PROTEUSS)
Subunit structure
Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding (By similarity). Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via
View this AlphaFold prediction interactively in 3D with MolViewer. Rotate, zoom, measure distances and angles, and explore the predicted structure directly in your browser without installing any software.