Q9Y6K9: NF-kappa-B essential modulator
NF-kappa-B essential modulator (IKBKG) is a 419-residue protein from Homo sapiens. UniProt accession: Q9Y6K9.
Function
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulati
Subcellular location
Cytoplasm, Nucleus
Disease associations
Ectodermal dysplasia and immunodeficiency 1 (EDAID1); Immunodeficiency 33 (IMD33); Incontinentia pigmenti (IP)
Subunit structure
Homodimer; disulfide-linked (PubMed:18164680). Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits (PubMed:11080499, PubMed:17977820, PubMed:18462684, PubMed:32935379, PubMed:9751060, PubMed:9891086). The IKK core complex seems to associate with regulatory or adapter prote
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