Transferrin receptor protein 1 (TfR1) is a 761-residue protein from Neotoma albigula. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: A0A060BIS8.
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The mean pLDDT of this model is 84.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway
Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells. Interacts with SNX32; the interaction is involved in intracellular trafficking of the receptor
Cell membrane, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6S9J | X-ray | 2.7 Å | A/C/E/G=190-384 |
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