Antibodies and the immune system

Antibodies are Y-shaped proteins that recognize foreign molecules with great precision using the loops at the tips of their arms. This collection shows whole antibodies, antibody fragments bound to their targets, and therapeutic antibodies used against cancer and autoimmune disease. It also includes the MHC molecules and T-cell receptors that let the immune system spot infected cells.

Open Intact mouse IgG2a antibody in 3D

29 structures

Intact mouse IgG2a antibody1IGT
Intact mouse IgG1 antibody1IGY
Intact human IgG1 antibody b12 against HIV1HZH
Human IgG1 antibody with a hinge deletion1MCO
Pembrolizumab, a full-length IgG4 antibody5DK3
Human Fc fragment with protein A1FC2
IgG1 Fc bound to Fc gamma receptor III1E4K
IgE Fc bound to its high-affinity receptor1F6A
This interaction triggers allergic reactions.
IgM Fc with J chain and polymeric Ig receptor6KXS
Dimeric secretory IgA6UE7
Antibody Fab D1.3 bound to lysozyme1FDL
Antibody Fab HyHEL-10 bound to lysozyme3HFM
Camel single-domain antibody bound to lysozyme1MEL
Single-domain antibodies from camels and llamas are also called nanobodies.
HER2 bound to trastuzumab (Herceptin) Fab1N8Z
HER2 bound to pertuzumab Fab1S78
EGFR bound to cetuximab Fab1YY9
TNF-alpha bound to adalimumab Fab3WD5
TNF-alpha bound to infliximab Fab4G3Y
PD-1 bound to pembrolizumab Fab5GGS
PD-1 bound to nivolumab Fab5WT9
VEGF bound to a neutralizing antibody Fab1BJ1
HIV gp120 bound to antibody VRC013NGB
HLA-B27 MHC class I molecule1HSA
Mouse MHC class I H-2Kb with a viral peptide2VAA
T-cell receptor bound to HLA-A2 and a viral peptide1AO7
T-cell receptor 2C bound to MHC H-2Kb2CKB
Human PD-1 (AlphaFold)Q15116 (AlphaFold)
Human PD-L1 (AlphaFold)Q9NZQ7 (AlphaFold)
Human CTLA-4 (AlphaFold)P16410 (AlphaFold)

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