AlphaFold highlights

AlphaFold is an AI system that predicts a protein's 3D structure from its amino acid sequence, and its creators shared the 2024 Nobel Prize in Chemistry. These predicted models cover famous human proteins, including several that are hard to study experimentally because they are large, flexible or embedded in membranes. Color by confidence (pLDDT) to see which parts of each model are reliable and which are likely disordered.

Open p53 tumor suppressor in 3D

22 structures

• p53 tumor suppressorP04637 (AlphaFold)
  The most frequently mutated gene in human cancer.
• BRCA1 breast cancer proteinP38398 (AlphaFold)
  Large parts of BRCA1 are predicted to be disordered.
• Tau proteinP10636 (AlphaFold)
• Alpha-synucleinP37840 (AlphaFold)
• Amyloid-beta precursor protein (APP)P05067 (AlphaFold)
• Apolipoprotein EP02649 (AlphaFold)
• Presenilin-1P49768 (AlphaFold)
• TREM2 microglial receptorQ9NZC2 (AlphaFold)
• CFTR chloride channelP13569 (AlphaFold)
• KRas GTPaseP01116 (AlphaFold)
• Epidermal growth factor receptor (EGFR)P00533 (AlphaFold)
• mTOR kinaseP42345 (AlphaFold)
• NEMO (NF-kappa-B essential modulator)Q9Y6K9 (AlphaFold)
• Insulin receptorP06213 (AlphaFold)
• hERG potassium channelQ12809 (AlphaFold)
• Cardiac sodium channel Nav1.5Q14524 (AlphaFold)
• Collagen alpha-1(I) chainP02452 (AlphaFold)
• Lamin A/CP02545 (AlphaFold)
• Coagulation factor VIIIP00451 (AlphaFold)
• Alpha-1-antitrypsinP01009 (AlphaFold)
• Serum albuminP02768 (AlphaFold)
• Hemoglobin subunit alphaP69905 (AlphaFold)

More collections

• Hemoglobin and oxygen transport
• Insulin and hormones
• SARS-CoV-2 and COVID-19
• DNA and RNA
• Enzymes: how proteins speed up chemistry
• Antibodies and the immune system
• Membrane proteins and transporters
• Photosynthesis
• Motor proteins and the cytoskeleton
• Ion channels
• GPCRs and cell signaling
• Kinases and cancer drug targets
• Viruses
• The ribosome and protein synthesis
• CRISPR and genome editing
• Fluorescent and glowing proteins
• Neurotransmission and the synapse
• Blood clotting
• Drugs bound to their targets
• Classic small proteins for teaching
• Metabolism and cellular energy
• Protein folding, misfolding and amyloid
• Toxins and how they work