Complement inhibitor RaCI3 is a 102-residue protein from Dermacentor andersoni. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0A146B485.
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The mean pLDDT of this model is 73.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 26% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Complement inhibitor (PubMed:27018802). Prevents complement-mediated C5 activation by binding to C5 (PubMed:27018802). Binds C5 at a different binding site than the other tick complement inhibitors OmCI and CirpT1, and the drug eculizumab (PubMed:27018802, PubMed:31871188). Inhibits complement in human and guinea pig but not in other species tested (rabbit, rat, mouse, and pig) (PubMed:27018802)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5HCC | X-ray | 2.59 Å | D=25-102 |
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