Non-homologous end-joining factor 1 (nhej1.S) is a 297-residue protein from Xenopus laevis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0A1L8ENT6.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:30177755, PubMed:33289484). It is also involved in telomere maintenance (By similarity). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (By similarity). In some studies, has been shown to associate with xrcc4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (By similarity). Alternatively, it has also been shown that rather than forming filaments, a single nhej1 dimer interacts through both head domains with xrcc4 to…
Homodimer (PubMed:30177755). Interacts with xrcc4; the interaction is direct and is mediated via a head-to-head interaction between N-terminal head regions (PubMed:30177755). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of prkdc/DNA-PKcs, lig4, xrcc4, xrcc6/Ku70, xrcc5/Ku80 and nhej1/xlf (PubMed:33289484)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.