Angiotensin-converting enzyme (ACE2) is a 807-residue protein from Urocitellus parryii. This is its AlphaFold structure prediction, created 31 Mar 2025. UniProt accession: A0A8D2KIZ1.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Homodimer. Interacts with the catalytically active form of TMPRSS2. Interacts with SLC6A19; this interaction is essential for expression and function of SLC6A19 in intestine. Interacts with ITGA5:ITGB1. Probably interacts (via endocytic sorting signal motif) with AP2M1; the interaction is inhibited by phosphorylation of Tyr-781. Interacts (via PDZ-binding motif) with NHERF1 (via PDZ domains);…
Apical cell membrane, Cell membrane, Cell projection, cilium, Cytoplasm, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9JR4 | X-ray | 2.76 Å | B=19-615 |
| 9JRC | X-ray | 3.16 Å | B=19-610 |
| 9JR5 | X-ray | 3.41 Å | A=19-615 |
| 9JR7 | X-ray | 3.43 Å | A=1-609 |
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