Ubiquitin-like modifier-activating enzyme 6 (UBA6) is a 1052-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0AVT1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility
Forms a thioester with UBD in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg) (PubMed:17889673, PubMed:25422469)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SOL | X-ray | 2.25 Å | A/C=37-1052 |
| 7PVN | X-ray | 2.71 Å | A/B=1-1052 |
| 9QH5 | EM | 3.09 Å | B=1-1052 |
| 7PYV | X-ray | 3.27 Å | A/B=1-623, A/B=900-1052 |
| 9QIC | EM | 3.29 Å | B=1-1052 |
| 9QIV | EM | 3.44 Å | B=1-1052 |
| 9QIM | EM | 3.57 Å | B=1-1052 |
| 9QGW | EM | 3.62 Å | B=1-1052 |
| 9QIG | EM | 3.94 Å | B=1-1052 |
| 9QII | EM | 3.99 Å | B=1-1052 |
| 9QIP | EM | 4.15 Å | B=1-1052 |
| 9QIO | EM | 4.22 Å | B=1-1052 |
| 9QHI | EM | 4.27 Å | B=1-1052 |
| 9QIA | EM | 4.38 Å | B=1-1052 |
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