ADP-ribose glycohydrolase MACROD2 (MACROD2) is a 425-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A1Z1Q3.
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The mean pLDDT of this model is 71.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746)
Interacts with ADP-ribosylated PARP1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IQY | X-ray | 1.55 Å | A/B=7-243 |
| 6Y73 | X-ray | 1.7 Å | A/B/C/D/E/F/G/H=7-243 |
| 6Y4Y | X-ray | 1.75 Å | A/B/C/D=7-243 |
| 6Y4Z | X-ray | 1.9 Å | A/B/C/D=7-243 |
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