Tubulin polyglutamylase TTLL6 (Ttll6) is a 822-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A4Q9E8.
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The mean pLDDT of this model is 64.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:32747782). Promotes tubulin polyglutamylation which stimulates…
Found in a complex with CEP41
Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, cilium axoneme, Cytoplasm, cytoskeleton, cilium basal body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6VZU | X-ray | 1.98 Å | A/B/C/D=51-503 |
| 6VZT | X-ray | 2.18 Å | A/B=51-503 |
| 6VZV | X-ray | 2.33 Å | A/B/C/D=51-503 |
| 6VZW | X-ray | 2.5 Å | A/B/C/D=51-503 |
| 6VZR | X-ray | 2.6 Å | A/B/C/D=51-503 |
| 6VZS | X-ray | 2.66 Å | A/B/C/D=51-503 |
| 6VZQ | X-ray | 3.08 Å | A/B/C/D=51-503 |
| 8T42 | EM | 3.6 Å | N=1-503 |
| 8U3Z | EM | 3.6 Å | N=1-822 |
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