Large-conductance mechanosensitive channel (mscL) is a 151-residue protein from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A5U127.
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The mean pLDDT of this model is 78.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Channel that opens in response to stretch forces in the membrane lipid bilayer. The force required to trigger channel opening depends on the nature of the membrane lipids; the presence of phosphatidylinositol enhances mechanosensitivity of the channel. May participate in the regulation of osmotic pressure changes within the cell
Homopentamer
Cell membrane
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
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