Fibrinogen-binding protein (fib) is a 165-residue protein from Staphylococcus aureus (strain Newman). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A6QG59.
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The mean pLDDT of this model is 79.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Extracellular fibrinogen-binding protein that plays an important role in virulence (PubMed:7934883, PubMed:8945578). By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation (PubMed:11418620). In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host. Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal (PubMed:24348255, PubMed:27112346)
Interacts with host fibrinogen alpha chain/FGA (PubMed:11418620). Interacts with host complement protein C3 (PubMed:11418620, PubMed:18687868, PubMed:24348255)
Secreted
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