Histone-lysine N-methyltransferase, H3 lysine-4 specific (SET1) is a 1080-residue protein from Saccharomyces cerevisiae (strain YJM789). This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: A6ZT27.
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The mean pLDDT of this model is 62.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face
Component of the COMPASS (Set1C) complex
Chromosome, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BX3 | EM | 4.3 Å | E=799-1076 |
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