Tubulin alpha chain is a 451-residue protein from Ovis aries. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: D0VWZ0.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13…
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5EYP | X-ray | 1.9 Å | A=1-451 |
| 3RYC | X-ray | 2.1 Å | A/C=1-451 |
| 9F07 | X-ray | 2.21 Å | A/E=1-451 |
| 4DRX | X-ray | 2.22 Å | A/C=1-437 |
| 6TDE | X-ray | 2.29 Å | A/C=1-451 |
| 3RYI | X-ray | 2.4 Å | A/C=1-451 |
| 5KX5 | X-ray | 2.5 Å | A/C=1-451 |
| 3RYF | X-ray | 2.52 Å | A/C=1-451 |
| 4F6R | X-ray | 2.64 Å | A=1-451 |
| 6GVN | X-ray | 2.69 Å | A=1-451 |
| 3UT5 | X-ray | 2.73 Å | A/C=1-451 |
| 6H9B | X-ray | 2.75 Å | A/C=1-440 |
| 3RYH | X-ray | 2.8 Å | A/C=1-451 |
| 4X1I | X-ray | 3.11 Å | A/C=1-451 |
| 4HNA | X-ray | 3.19 Å | A=1-451 |
| 4X1Y | X-ray | 3.19 Å | A/C=1-451 |
| 6GX7 | X-ray | 3.19 Å | A/C=1-451 |
| 4EB6 | X-ray | 3.47 Å | A/C=1-451 |
| 4X1K | X-ray | 3.5 Å | A/C=1-451 |
| 4X20 | X-ray | 3.5 Å | A/C=1-451 |
Showing 20 of 28 experimental structures (best resolution first).
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