Cilia- and flagella-associated protein 70 (Cfap70) is a 1141-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: D3YVL2.
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The mean pLDDT of this model is 75.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Axoneme-binding protein that plays a role in the regulation of ciliary motility and cilium length (PubMed:30158508). Essential for the assembly of the sperm flagellum and the correct shaping of the sperm head, during spermiogenesis (PubMed:37458246, PubMed:37352829). Contributes in part to flagellar biogenesis by stabilizing QRICH2, promoting the cytoplasmic preassembly of CFAP61 and CFAP91, and regulating the manchette localization of axoneme-associated proteins such as IFT88, DNAI1 and CFAP61 (PubMed:37352829)
Interacts with MYCBPAP (PubMed:39092789, PubMed:39704931). Interacts with CFAP65 (PubMed:39853433). Interacts with DNAI1 and DNAI2 (PubMed:37458246, PubMed:37352829). Interacts with QRICH2, CFAP61 and CFAP91 (PubMed:37352829)
Cell projection, cilium, flagellum, Cytoplasm, cytoskeleton, flagellum basal body, Cell projection, cilium, Cytoplasm, cytoskeleton, cilium axoneme, Cytoplasm, cytoskeleton, flagellum axoneme
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9IJJ | EM | 7.7 Å | k/l/m/n/o/p=1-1141 |
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