Envelope glycoprotein L (gL) is a 278-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: F5HCH8.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 54% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH (By similarity). In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2 (PubMed:28403202, PubMed:37146061). The…
Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH (By similarity). Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A (PubMed:17942555). The pentamer interacts with host NRP2 (PubMed:30057110). Forms the envelope trimer complex composed of gH, gL, and gO (PubMed:33626330). The trimer…
Virion membrane, Host cell membrane, Host Golgi apparatus, host trans-Golgi network
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7LBG | EM | 2.6 Å | B=1-278 |
| 7LBF | EM | 2.8 Å | B=1-278 |
| 7LBE | EM | 2.9 Å | B=1-278 |
| 7T4Q | EM | 2.9 Å | B=1-278 |
| 7T4S | EM | 3.1 Å | B=1-278 |
| 7T4R | EM | 3.3 Å | C/L=1-278 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.