Envelope glycoprotein UL130 (UL130) is a 214-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: F5HCP3.
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The mean pLDDT of this model is 68.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:17942555, PubMed:23853586, PubMed:28783665). Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110)
Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A. The pentamer interacts with host NRP2
Virion membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T4Q | EM | 2.9 Å | D=1-214 |
| 5VOB | X-ray | 3.02 Å | D=1-214 |
| 7T4S | EM | 3.1 Å | D=1-214 |
| 7T4R | EM | 3.3 Å | E/N=1-214 |
| 5VOC | X-ray | 3.99 Å | D=1-214 |
| 5VOD | X-ray | 5.9 Å | D=1-214 |
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