Protein ORF45 (ORF45) is a 407-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: F5HDE4.
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The mean pLDDT of this model is 48.2 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta (PubMed:11943871, PubMed:20485504, PubMed:22787218). Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate (PubMed:11943871, PubMed:22787218). Acts as an activator of the NLRP1 inflammasome via interaction with the N-terminal part of host NLRP1: interaction promotes translocation of the N-terminal part of NLRP1 into the nucleus, relieving autoinhibition of the NLRP1…
Interacts with host IRF7 (PubMed:11943871). Interacts with host RPS6KA1 (PubMed:30842327). Interacts with host RAB11FIP5; this interaction results in the lysosomal degradation of ORF45 and the inhibition of viral particle release (PubMed:33315947). Interacts with host p53/TP53; this interaction down-regulates p53/TP53 signaling pathway (PubMed:34523970). Interacts with the N-terminal part of…
Virion tegument, Host cytoplasm, Host nucleus, Host Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
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