Protein UL131A (UL131A) is a 129-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: F5HET4.
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The mean pLDDT of this model is 59.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:17942555, PubMed:23853586). Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110). Contributes to the formation of the complex between UL128, UL130 and gH-gL
Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A. The pentamer interacts with host NRP2 (PubMed:17942555, PubMed:28783665, PubMed:30057110). The interaction with gH is important for the formation of UL128, UL130, gH-gL complex (PubMed:16894182)
Virion membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T4Q | EM | 2.9 Å | E=1-129 |
| 5VOB | X-ray | 3.02 Å | E=1-129 |
| 7T4S | EM | 3.1 Å | E=1-129 |
| 7T4R | EM | 3.3 Å | F/O=1-129 |
| 7M22 | EM | 3.65 Å | E=19-129 |
| 7M30 | EM | 3.81 Å | E=19-129 |
| 5VOC | X-ray | 3.99 Å | E=1-129 |
| 7KBB | EM | 4.02 Å | E=19-129 |
| 5VOD | X-ray | 5.9 Å | E=1-129 |
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