VIRF-1 (vIRF-1) is a 449-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 1 Jan 2024. UniProt accession: F5HF68.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP. Regulates the host cellular metabolism by increasing glucose uptake, ATP production and lactate secretion through down-regulation of heterogeneous nuclear ribonuclear protein Q1/SYNCRIP. Mechanistically, induces ubiquitination and degradation of SYNCRIP through the ubiquitin-proteasome pathway by recruiting KLHL3/CUL3 ubiquitin ligase complex (PubMed:35538151). Disrupts host TP53 signaling pathway during viral infection by interacting with host USP7 and thereby…
Forms homodimers (PubMed:37459327). Interacts with host IRF3, IRF7, and CREBBP (PubMed:11314014). Interacts with host SYNCRIP (PubMed:35538151). Interacts with host USP7 (PubMed:26786098). Interacts (via C-terminus) with host HERC5 (PubMed:26355087). Interacts with host GABARAPL1 (PubMed:37459327). Interacts with host SIRT6 (PubMed:37023208)
Host cytoplasm
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