FACT complex subunit (CTHT_0052370) is a 1029-residue protein from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719). This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: G0SDN1.
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The mean pLDDT of this model is 81.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II
Component of the FACT complex
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4KHO | X-ray | 2.0 Å | A/B=651-945 |
| 4KHA | X-ray | 2.35 Å | A=652-945 |
| 4KHB | X-ray | 2.4 Å | A/C/E/G=521-647 |
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