Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) is a 284-residue protein from Oryctolagus cuniculus. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: G1T2G4.
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The mean pLDDT of this model is 72.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 62% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain. eIF2 is member of the 43S pre-initiation complex (43S PIC). eIF2 forms a complex with at least CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation. Interacts with…
Cytoplasm, Stress granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9H6Y | EM | 2.9 Å | A=1-284 |
| 9H74 | EM | 2.9 Å | A=1-284 |
| 6YAL | EM | 3.0 Å | A=1-284 |
| 8P03 | EM | 3.04 Å | A=1-284 |
| 8P09 | EM | 3.3 Å | A=1-284 |
| 6YAN | EM | 3.48 Å | A=6-271 |
| 6YAM | EM | 3.6 Å | A=6-271 |
| 5K0Y | EM | 5.8 Å | P=6-271 |
| 9CPA | EM | 6.0 Å | A=1-284 |
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