G5EGS3: Kinesin-like protein klp-12 (klp-12)

Kinesin-like protein klp-12 (klp-12) is a 1605-residue protein from Caenorhabditis elegans. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: G5EGS3.

Gene
klp-12
Organism
Caenorhabditis elegans
Length
1605 residues
Mean pLDDT
69.4
Model
AF-G5EGS3-F1 v6
Model created
1 Aug 2025
PDB structures
1

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Model confidence (pLDDT)

The mean pLDDT of this model is 69.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate20%
70 to 90Confident: backbone generally right43%
50 to 70Low: treat with caution13%
Below 50Very low: often disordered regions24%

What pLDDT means and how to read it

Function

Microtubule-binding motor protein which has ATPase activity (PubMed:36065637). In complex with alpha and beta tubulins, preferentially binds to the growing microtubule plus-end to stabilize it and detaches following ATP hydrolysis (PubMed:36065637). Negatively regulates axonal length through inhibiting microtubule polymerization at its plus-end (PubMed:36065637)

Subunit structure

Component of a complex at least composed of alpha tubulin and beta tubulin (PubMed:36065637). Within the complex, interacts with the alpha tubulin and beta tubulin dimer (PubMed:36065637)

Subcellular location

Cytoplasm, cytoskeleton

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
7X4NX-ray2.88 ÅE=1-365

More AlphaFold highlights

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