Mitochondrial ribosome and complex I assembly factor AltMIEF1 (MIEF1) is a 70-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: L0R8F8.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes) (PubMed:28892042, PubMed:30215512, PubMed:31666358). Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possibly preventing premature association of the large and small ribosomal subunits (PubMed:28892042, PubMed:30215512, PubMed:31666358). Thereby, indirectly regulates mitochondrial translation (PubMed:28892042, PubMed:30215512, PubMed:31666358). It is also required for complete assembly of the mitochondrial respiratory chain complex I (PubMed:31666358). May also function in DNM1L-mediated…
Interacts with intermediates of the mitochondrial ribosome large subunit (mt-LSU) (via MALSU1 as part of a complex that also contains NDUFAB1); regulates mitochondrial ribosomes assembly (PubMed:28892042, PubMed:30215512, PubMed:31666358, PubMed:35177605). Interacts with MRPL4 (PubMed:30215512). Interacts with MRPS27 (PubMed:30215512)
Mitochondrion matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OF0 | EM | 2.2 Å | v=1-70 |
| 8QU5 | EM | 2.42 Å | v=1-70 |
| 7O9M | EM | 2.5 Å | v=1-70 |
| 7OF7 | EM | 2.5 Å | v=1-70 |
| 7PO4 | EM | 2.56 Å | zb=1-70 |
| 7OF2 | EM | 2.7 Å | v=1-70 |
| 7OF3 | EM | 2.7 Å | v=1-70 |
| 7QH7 | EM | 2.89 Å | v=2-70 |
| 7ODR | EM | 2.9 Å | v=1-70 |
| 7OF5 | EM | 2.9 Å | v=1-70 |
| 8QSJ | EM | 3.0 Å | v=1-70 |
| 5OOM | EM | 3.03 Å | v=1-70 |
| 8PK0 | EM | 3.03 Å | v=1-70 |
| 5OOL | EM | 3.06 Å | v=1-70 |
| 7QH6 | EM | 3.08 Å | v=1-70 |
| 7A5J | EM | 3.1 Å | v=1-70 |
| 7O9K | EM | 3.1 Å | v=1-70 |
| 7ODS | EM | 3.1 Å | v=1-70 |
| 7ODT | EM | 3.1 Å | v=1-70 |
| 7OIC | EM | 3.1 Å | v=1-70 |
Showing 20 of 29 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.