Complement inhibitor CirpT1 is a 111-residue protein from Rhipicephalus pulchellus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: L7MB58.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Complement inhibitor (PubMed:31871188). Prevents complement-mediated activation of C5 by sterically preventing direct binding of C5 to its convertase (binding with domains MG4 and MG5) (PubMed:31871188). Binds C5 at a different binding site than the other tick complement inhibitors OmCI and RaCI3, and the drug eculizumab (PubMed:31871188). Inhibits the complement in human, rat and guinea pig, and also shows a reduced inhibition in rabbit and pig (PubMed:31871188)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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