Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) is a 1044-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00329.
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The mean pLDDT of this model is 87.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR)…
Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS (By similarity). Interacts with HRAS. Interacts (via the catalytic domain) with FOXM1 isoform 5 (FOXM1D); FOXM1D also simultaneously binds to the PI3K regulatory subunit which relieves the inhibitory effect of the regulatory subunit on the kinase activity of the catalytic…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6PYR | X-ray | 2.21 Å | A=17-1034 |
| 8S3R | X-ray | 2.28 Å | A=17-1034 |
| 7JIS | X-ray | 2.42 Å | A=17-1034 |
| 8BCY | X-ray | 2.43 Å | A=17-1034 |
| 9L3R | X-ray | 2.5 Å | A=1-1044 |
| 6PYU | X-ray | 2.54 Å | A=17-1034 |
| 6OCO | X-ray | 2.58 Å | A=17-1031 |
| 5DXU | X-ray | 2.64 Å | A=2-1044 |
| 6G6W | X-ray | 2.72 Å | A=1-1044 |
| 6OCU | X-ray | 2.77 Å | A=1-1044 |
| 7LM2 | X-ray | 2.79 Å | A=12-1031 |
| 5VLR | X-ray | 2.8 Å | A=17-1029 |
| 9GDI | X-ray | 2.81 Å | A=1-1044 |
| 5UBT | X-ray | 2.83 Å | A=17-1029 |
| 5M6U | X-ray | 2.85 Å | A=17-1027 |
| 9GCF | X-ray | 2.89 Å | A=1-1044 |
| 5T8F | X-ray | 2.91 Å | A=17-1031 |
| 7LQ1 | X-ray | 2.96 Å | A=1-1044 |
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