Voltage-gated inwardly rectifying potassium channel KCNH2 (Kcnh2) is a 1163-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O08962.
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The mean pLDDT of this model is 62.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9664620). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:11212207, PubMed:9664620). Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (By similarity)
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Interacts with DNAJB12 and DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization (By similarity). Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (PubMed:11212207). Interacts with ALG10B (PubMed:14525949). Forms a stable…
Cell membrane
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
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