Suppressor of cytokine signaling 2 (SOCS2) is a 198-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14508.
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The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (PubMed:11781573, PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by…
Substrate-recognition component of the ECS(SOCS2) complex, composed of SOCS2, CUL5, ELOB, ELOC and RNF7/RBX2 (PubMed:16675548, PubMed:21980433, PubMed:23897481, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). Interacts with IGF1R (PubMed:9727029). Interacts with DCUN1D1 (PubMed:23401859)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7ZLM | X-ray | 1.79 Å | A/D/G/J=32-198 |
| 2C9W | X-ray | 1.9 Å | A=30-198 |
| 7ZLS | X-ray | 1.92 Å | A/D/G/J=32-198 |
| 7ZLP | X-ray | 1.94 Å | A=32-198 |
| 6I5N | X-ray | 1.98 Å | A/D=30-198 |
| 7ZLR | X-ray | 2.01 Å | A=32-198 |
| 7ZLO | X-ray | 2.22 Å | A=32-198 |
| 7ZLN | X-ray | 2.6 Å | A=32-198 |
| 6I4X | X-ray | 2.69 Å | A=30-198 |
| 6I5J | X-ray | 2.8 Å | A/D=30-198 |
| 5BO4 | X-ray | 2.9 Å | A/D/G/J/M/P=32-198 |
| 4JGH | X-ray | 3.0 Å | A=32-198 |
| 7M6T | X-ray | 3.19 Å | A=32-198 |
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