Serine/threonine-protein kinase Chk1 (CHEK1) is a 476-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14757.
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The mean pLDDT of this model is 76.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615,…
Interacts (phosphorylated by ATR) with RAD51 (PubMed:15665856). Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1 (PubMed:16963448). Interacts with BRCA1 (PubMed:11836499). Interacts with and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511). Interacts with FBXO6, which regulates CHEK1 (PubMed:19716789). Interacts with…
Nucleus, Chromosome, Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2YEX | X-ray | 1.3 Å | A=1-276 |
| 9CE4 | X-ray | 1.31 Å | A=4-271 |
| 3PA3 | X-ray | 1.4 Å | A=2-274 |
| 4HYI | X-ray | 1.4 Å | A=1-289 |
| 5OQ5 | X-ray | 1.4 Å | A=1-289 |
| 3OT3 | X-ray | 1.44 Å | A=2-274 |
| 7SUF | X-ray | 1.48 Å | A=1-289 |
| 7SUG | X-ray | 1.48 Å | A=1-289 |
| 8E80 | X-ray | 1.49 Å | A=1-289 |
| 5OPB | X-ray | 1.55 Å | A=1-289 |
| 5OPU | X-ray | 1.55 Å | A=1-289 |
| 8SIX | X-ray | 1.55 Å | A=1-289 |
| 3PA4 | X-ray | 1.59 Å | A=2-274 |
| 2YDI | X-ray | 1.6 Å | A=1-289 |
| 3TKI | X-ray | 1.6 Å | A=1-307 |
| 6FC8 | X-ray | 1.61 Å | A=1-276 |
| 8E81 | X-ray | 1.62 Å | A=1-289 |
| 3OT8 | X-ray | 1.65 Å | A=2-274 |
| 7MCK | X-ray | 1.65 Å | A=1-289 |
| 10HZ | X-ray | 1.67 Å | A=1-289 |
Showing 20 of 163 experimental structures (best resolution first).
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