DNA-directed RNA polymerase III subunit RPC1 (POLR3A) is a 1390-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14802.
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The mean pLDDT of this model is 88.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:19609254, PubMed:19631370, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192, PubMed:9331371). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription…
Component of the RNA polymerase III (Pol III) (Pol III) complex consisting of 17 subunits: a ten-subunit catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in…
Nucleus, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AE1 | EM | 2.8 Å | A=1-1390 |
| 9K39 | EM | 2.8 Å | A=1-1390 |
| 7D58 | EM | 2.9 Å | A=1-1390 |
| 9K36 | EM | 2.9 Å | A=1-1390 |
| 9K2G | EM | 3.0 Å | A=1-1390 |
| 9K3U | EM | 3.0 Å | A=1-1390 |
| 7AE3 | EM | 3.1 Å | A=1-1390 |
| 7D59 | EM | 3.1 Å | A=1-1390 |
| 9K38 | EM | 3.1 Å | A=1-1390 |
| 9FSO | EM | 3.28 Å | A=1-1390 |
| 7A6H | EM | 3.3 Å | A=1-1390 |
| 9LXN | EM | 3.3 Å | A=1-1390 |
| 7DU2 | EM | 3.35 Å | A=1-1390 |
| 9FSP | EM | 3.39 Å | A=1-1390 |
| 7AEA | EM | 3.4 Å | A=1-1390 |
| 8IUH | EM | 3.4 Å | A=1-1390 |
| 7DN3 | EM | 3.5 Å | A=1-1390 |
| 9K3V | EM | 3.5 Å | A=1-1390 |
| 9LKT | EM | 3.5 Å | A=1-1390 |
| 9FSQ | EM | 3.51 Å | A=1-1390 |
Showing 20 of 29 experimental structures (best resolution first).
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