Orexin receptor type 2 (HCRTR2) is a 444-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43614.
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The mean pLDDT of this model is 78.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:26950369, PubMed:33547286, PubMed:35614071, PubMed:9491897). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (PubMed:35614071). Involved in regulating the sleep-wake cycle (By similarity). Contributes to central regulation of glucose homeostasis (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5WQC | X-ray | 1.96 Å | A=3-254, A=294-386 |
| 5WS3 | X-ray | 2.3 Å | A=3-254, A=294-388 |
| 4S0V | X-ray | 2.5 Å | A=3-254, A=294-388 |
| 6TPN | X-ray | 2.61 Å | A=1-254, A=294-388 |
| 6TPG | X-ray | 2.74 Å | A=1-254, A=294-388 |
| 6TPJ | X-ray | 2.74 Å | A/B=1-254, A/B=294-388 |
| 7XRR | X-ray | 2.89 Å | A=33-394 |
| 7L1V | EM | 3.0 Å | R=3-389 |
| 7SQO | EM | 3.17 Å | R=1-444 |
| 7L1U | EM | 3.2 Å | R=3-389 |
| 7SR8 | EM | 3.3 Å | R=3-408 |
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