Neuropilin-2 (NRP2) is a 931-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60462.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF
Heterodimer with NRP1. Binds PLXNB1
Membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TJT | X-ray | 1.31 Å | A/B=275-430 |
| 5DQ0 | X-ray | 1.8 Å | A=275-430 |
| 8IVX | X-ray | 1.9 Å | A=25-595 |
| 2QQJ | X-ray | 1.95 Å | A=275-595 |
| 4QDQ | X-ray | 1.95 Å | A/B=276-595 |
| 5DN2 | X-ray | 1.95 Å | A/B/C/D=275-429 |
| 2QQO | X-ray | 2.3 Å | A/B=145-595 |
| 4QDR | X-ray | 2.4 Å | A=276-595 |
| 4QDS | X-ray | 2.4 Å | A/B=275-457 |
| 6GH8 | X-ray | 2.44 Å | A/C=27-146 |
| 6TDB | X-ray | 2.45 Å | A/B/C/D=275-430 |
| 2QQK | X-ray | 2.75 Å | A=23-595 |
| 2QQL | X-ray | 3.1 Å | A=23-595 |
| 7T4S | EM | 3.1 Å | F=1-864 |
| 8IVW | X-ray | 3.21 Å | A/D/G/J=25-595 |
| 7M22 | EM | 3.65 Å | N=23-595 |
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