Histone H2B type 1-K (H2BC12) is a 126-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60814.
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The mean pLDDT of this model is 87.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9ECP | EM | 1.91 Å | D/H=32-125 |
| 8Q3E | X-ray | 2.17 Å | DDD/HHH=32-126 |
| 6KE9 | X-ray | 2.22 Å | D/H=32-126 |
| 8Q3X | X-ray | 2.3 Å | DDD/HHH=32-126 |
| 2CV5 | X-ray | 2.5 Å | D/H=1-126 |
| 8Q3M | X-ray | 2.5 Å | DDD/HHH=32-126 |
| 7XCR | EM | 2.57 Å | D/H=32-125 |
| 6L9H | X-ray | 2.6 Å | D/H=32-126 |
| 6LE9 | X-ray | 2.6 Å | D/H=32-126 |
| 8Q36 | X-ray | 2.6 Å | DDD/HHH=32-126 |
| 7XCT | EM | 2.72 Å | D/H=33-125 |
| 8YV8 | EM | 3.0 Å | D/H=2-126 |
| 8HR1 | EM | 3.02 Å | D/H=35-125 |
| 8GRM | EM | 3.05 Å | D=31-126, H=32-126 |
| 8HQY | EM | 3.05 Å | D/H=35-125 |
| 8WG5 | EM | 3.05 Å | D/H=32-125 |
| 9ZEO | EM | 3.1 Å | D/H=32-126 |
| 8IEJ | EM | 3.12 Å | D/H=32-125 |
| 9U5U | EM | 3.12 Å | D/H=2-126 |
| 6Y5E | EM | 3.15 Å | D=33-125, H=32-125 |
Showing 20 of 83 experimental structures (best resolution first).
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