Nuclear receptor corepressor 1 (NCOR1) is a 2440-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75376.
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The mean pLDDT of this model is 40.8 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 82% |
What pLDDT means and how to read it
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene…
Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XZZ | X-ray | 1.39 Å | B=1726-1742 |
| 8FKC | X-ray | 1.42 Å | D=2256-2278 |
| 6XYX | X-ray | 1.44 Å | C/D=1340-1356 |
| 6Y17 | X-ray | 1.56 Å | A/B=1733-1741, C/D=1340-1356 |
| 8DKV | X-ray | 1.59 Å | C=2259-2272 |
| 6ONI | X-ray | 1.8 Å | D=2256-2278 |
| 8FHE | X-ray | 1.8 Å | D=2256-2278 |
| 8FHG | X-ray | 1.8 Å | D=2256-2278 |
| 8FKF | X-ray | 1.82 Å | D=2256-2278 |
| 8DKN | X-ray | 1.95 Å | C=2260-2272 |
| 6WMS | X-ray | 2.0 Å | E/F=2256-2278 |
| 8FKE | X-ray | 2.02 Å | D=2256-2278 |
| 3KMZ | X-ray | 2.1 Å | C/D=2047-2065 |
| 9O9N | X-ray | 2.1 Å | D=2256-2278 |
| 8FKG | X-ray | 2.12 Å | D=2256-2278 |
| 8FKD | X-ray | 2.22 Å | D=2256-2278 |
| 4MDD | X-ray | 2.4 Å | C/D=2260-2274 |
| 6ZBU | X-ray | 2.46 Å | A/B/E/F/I/J=1733-1741, C/D/G/H/K/L=1340-1356 |
| 8D8I | X-ray | 2.5 Å | B=2045-2064 |
| 6WMQ | X-ray | 2.55 Å | E/F=2044-2066 |
Showing 20 of 27 experimental structures (best resolution first).
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