Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is a 907-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75473.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development
Identified in a complex composed of RNF43, LGR5 and RSPO1 (PubMed:21693646, PubMed:21727895, PubMed:21909076, PubMed:22815884, PubMed:23756651, PubMed:23809763). Also interacts with other R-spondin ligands, including RSPO2, RSPO3 and RSPO4 (PubMed:21693646, PubMed:21727895, PubMed:21909076, PubMed:29769720)
Cell membrane, Golgi apparatus, trans-Golgi network membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4UFR | X-ray | 2.2 Å | A/C=32-486 |
| 4KNG | X-ray | 2.5 Å | A/B=32-557 |
| 4BSR | X-ray | 3.2 Å | A/B=22-543 |
| 4BSS | X-ray | 3.2 Å | A/B/E/F=22-543 |
| 4BSU | X-ray | 3.2 Å | A/B/E/F=22-543 |
| 4BST | X-ray | 4.3 Å | A/B=22-543 |
| 4UFS | X-ray | 4.8 Å | A=32-486 |
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