Epsin-1 (Epn1) is a 575-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O88339.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:11161217). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (PubMed:12353027, PubMed:9723620). Regulates receptor-mediated endocytosis (By similarity)
Monomer. Binds ITSN1 (By similarity). Binds clathrin, ZBTB16/ZNF145, AP2A1 and AP2A2. Binds ubiquitinated proteins. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2 (By similarity). Interacts with REPS2; the interaction is direct (By similarity). Interacts with EPS15; the interaction is direct (By…
Cytoplasm, Cell membrane, Nucleus, Membrane, clathrin-coated pit
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1EYH | X-ray | 1.56 Å | A=15-158 |
| 1H0A | X-ray | 1.7 Å | A=1-158 |
| 1EDU | X-ray | 1.8 Å | A=12-160 |
| 1KY6 | X-ray | 2.0 Å | P=375-381 |
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