Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Hcn2) is a 863-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O88703.
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The mean pLDDT of this model is 71.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10962006, PubMed:11096117, PubMed:11459060, PubMed:11741901, PubMed:12034718, PubMed:12193608, PubMed:12968185, PubMed:17562314, PubMed:21347269, PubMed:21903816, PubMed:23103389). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (PubMed:21903816)
Homotetramer (Probable) (PubMed:12968185, PubMed:18367452, PubMed:19525958). The channel is composed of a homo- or heterotetrameric complex of pore-forming subunits (PubMed:12034718, PubMed:12928435, PubMed:12968185, PubMed:18367452). Heterotetramer with HCN1 (PubMed:12034718, PubMed:12928435). Forms an obligate 4:4 complex with accessory subunit PEX5L; regulates HCN2 cell-surface expression and…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3BPZ | X-ray | 1.65 Å | A/B/C/D=443-640 |
| 5KHH | X-ray | 1.77 Å | A=443-643 |
| 1Q3E | X-ray | 1.9 Å | A/B=443-645 |
| 3ETQ | X-ray | 1.9 Å | A/B=443-640 |
| 1Q43 | X-ray | 2.0 Å | A/B=443-645 |
| 5KHJ | X-ray | 2.01 Å | A/B=443-643 |
| 5JON | X-ray | 2.04 Å | A/B=494-640 |
| 5KHK | X-ray | 2.07 Å | A=443-643 |
| 5KHI | X-ray | 2.1 Å | A=443-643 |
| 5KHG | X-ray | 2.24 Å | A=443-643 |
| 2Q0A | X-ray | 2.25 Å | A/B=443-640 |
| 1Q5O | X-ray | 2.3 Å | A=443-645 |
| 3FFQ | X-ray | 2.4 Å | A/B=443-640 |
| 4EQF | X-ray | 3.0 Å | B=857-863 |
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