Autophagy-related protein 8 (atg8) is a 121-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O94272.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Ubiquitin-like modifier involved in autophagosome formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The…
Interacts with atg43 (via N-terminal atg8 interacting motif); the interaction is direct (PubMed:33138913). Interacts with atg38 (via AIM motif); the interaction is direct and leads to recruitment of the autophagy-specific vps34 PI3-kinase complex I to the phagophore assembly site (PubMed:31941401). Interacts with hfl1 (PubMed:33138913)
Cytoplasmic vesicle, autophagosome membrane, Vacuole membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6AAF | X-ray | 2.2 Å | A=1-116 |
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