Mitochondrial pyruvate carrier 2 (MPC2) is a 127-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O95563.
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The mean pLDDT of this model is 89.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628558, PubMed:26253029, PubMed:27317664, PubMed:29472561, PubMed:40044865, PubMed:40101766, PubMed:35278701). Plays an essential role in cellular metabolism (PubMed:40044865, PubMed:40101766)
Heterodimer; dimerises with MPC1 or MPC1L to form a functional mitochondrial pyruvate carrier (PubMed:26253029, PubMed:32403431, PubMed:40101766, PubMed:40044865, PubMed:35278701). May form a homodimer (PubMed:32403431)
Mitochondrion inner membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9MNZ | EM | 2.73 Å | B=1-127 |
| 9MNY | EM | 2.78 Å | B=1-127 |
| 9MO0 | EM | 2.83 Å | B=1-127 |
| 8YW9 | EM | 3.01 Å | B=1-127 |
| 9MNX | EM | 3.11 Å | B=1-127 |
| 8YW8 | EM | 3.17 Å | B=1-127 |
| 8YW6 | EM | 3.18 Å | B=1-127 |
| 9O9T | EM | 3.31 Å | B=1-124 |
| 9MNW | EM | 3.35 Å | B=1-127 |
| 9KNY | EM | 3.4 Å | B=1-127 |
| 9KNW | EM | 3.41 Å | B=1-127 |
| 9O9S | EM | 3.57 Å | B=1-124 |
| 9GIV | EM | 3.65 Å | B=1-127 |
| 9GIX | EM | 3.65 Å | B=1-127 |
| 9KNX | EM | 3.72 Å | B=1-127 |
| 9GIY | EM | 3.79 Å | B=1-127 |
| 9GIW | EM | 3.92 Å | B=1-127 |
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