Glutamate dehydrogenase 1, mitochondrial (GLUD1) is a 558-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00367.
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The mean pLDDT of this model is 90.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)
Homohexamer (By similarity). Interacts with HADH; this interaction inhibits the activation of GLUD1 (By similarity)
Mitochondrion, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8SK8 | EM | 2.31 Å | A/B/C/D/E/F=1-558 |
| 8KGY | EM | 2.59 Å | A/B/C/D/E/F=1-558 |
| 1L1F | X-ray | 2.7 Å | A/B/C/D/E/F=54-558 |
| 6DQG | X-ray | 2.7 Å | A/B/C/D/E/F=63-558 |
| 8W4J | EM | 3.06 Å | A/B/C/D/E/F=1-558 |
| 7UZM | EM | 3.24 Å | A/B/C/D/E/F=1-558 |
| 1NR1 | X-ray | 3.3 Å | A/B/C/D/E/F=63-558 |
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