Cytochrome c oxidase subunit 1 (MT-CO1) is a 514-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00396.
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The mean pLDDT of this model is 95.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons…
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A2 (or COX6A1), COX6B1 (or COX6B2), COX6C, COX7A1 (or COX7A2), COX7B, COX7C, COX8B and COXFA4, which are…
Mitochondrion inner membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7COH | X-ray | 1.3 Å | A/N=1-514 |
| 7W3E | X-ray | 1.45 Å | A/N=1-514 |
| 5B1A | X-ray | 1.5 Å | A/N=1-514 |
| 7YPY | X-ray | 1.5 Å | A/N=1-514 |
| 5B1B | X-ray | 1.6 Å | A/N=1-514 |
| 7VUW | X-ray | 1.6 Å | A/N=1-514 |
| 9M56 | X-ray | 1.6 Å | A/N=1-514 |
| 5ZCP | X-ray | 1.65 Å | A/N=1-514 |
| 5ZCQ | X-ray | 1.65 Å | A/N=1-514 |
| 7VVR | X-ray | 1.65 Å | A/N=1-514 |
| 5B3S | X-ray | 1.68 Å | A/N=1-514 |
| 7EV7 | X-ray | 1.7 Å | A/N=1-514 |
| 8H8R | X-ray | 1.7 Å | A/N=1-514 |
| 8H8S | X-ray | 1.7 Å | A/N=1-514 |
| 7D5X | X-ray | 1.74 Å | A/N=1-514 |
| 9IKF | X-ray | 1.75 Å | A/N=1-514 |
| 9IKH | X-ray | 1.75 Å | A/N=1-514 |
| 9IKI | X-ray | 1.75 Å | A/N=1-514 |
| 7CP5 | X-ray | 1.76 Å | A/N=1-514 |
| 5XDQ | X-ray | 1.77 Å | A/N=1-514 |
Showing 20 of 91 experimental structures (best resolution first).
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