Hirudin variant-1 is a 65-residue protein from Hirudo medicinalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01050.
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The mean pLDDT of this model is 90.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2UUF | X-ray | 1.26 Å | H=55-64 |
| 2UUJ | X-ray | 1.32 Å | H=55-64 |
| 2UUK | X-ray | 1.39 Å | H=55-64 |
| 1H8D | X-ray | 1.4 Å | I=55-64 |
| 2ZFF | X-ray | 1.47 Å | I=54-64 |
| 3D49 | X-ray | 1.5 Å | I=54-64 |
| 4YES | X-ray | 1.5 Å | H=54-65 |
| 3EQ0 | X-ray | 1.53 Å | I=54-64 |
| 3UTU | X-ray | 1.55 Å | I=54-64 |
| 2ZC9 | X-ray | 1.58 Å | I=54-64 |
| 1AHT | X-ray | 1.6 Å | I=55-64 |
| 2ZGB | X-ray | 1.6 Å | I=54-64 |
| 3DUX | X-ray | 1.6 Å | I=54-64 |
| 7A0D | X-ray | 1.6 Å | III=1-65 |
| 4LXB | X-ray | 1.61 Å | I=53-65 |
| 2ZI2 | X-ray | 1.65 Å | I=54-64 |
| 2ZIQ | X-ray | 1.65 Å | I=54-64 |
| 2ZO3 | X-ray | 1.7 Å | I=54-64 |
| 2ZDV | X-ray | 1.72 Å | I=54-64 |
| 2ZDA | X-ray | 1.73 Å | I=54-64 |
Showing 20 of 74 experimental structures (best resolution first).
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