Pro-opiomelanocortin (POMC) is a 267-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01189.
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The mean pLDDT of this model is 57.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 43% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4XNH | X-ray | 2.1 Å | F=138-145 |
| 8INR | EM | 2.73 Å | L=138-150 |
| 4XPD | X-ray | 2.81 Å | F=138-145 |
| 7PIV | EM | 2.86 Å | P=138-150 |
| 8IOC | EM | 2.86 Å | L=77-87 |
| 8W8W | EM | 2.9 Å | L=138-150 |
| 8W8X | EM | 2.9 Å | L=217-234 |
| 8W8Y | EM | 2.9 Å | L=77-87 |
| 7F53 | EM | 3.0 Å | L=138-150 |
| 7F54 | EM | 3.0 Å | L=138-150 |
| 8F7Q | EM | 3.22 Å | P/Q=237-267 |
| 4Y49 | X-ray | 3.95 Å | E/K/Q=138-145 |
| 6TUB | NMR | A/B/C/D/E/F=237-267 |
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