Proenkephalin-A (PENK) is a 267-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01210.
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The mean pLDDT of this model is 60.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 45% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5E33 | X-ray | 1.84 Å | B=261-265 |
| 5E3A | X-ray | 2.05 Å | B=230-234 |
| 8JGF | EM | 2.7 Å | L=217-231 |
| 8DWG | EM | 2.71 Å | A=217-231 |
| 8DWC | EM | 2.87 Å | A=217-231 |
| 8JGG | EM | 3.0 Å | L=220-230 |
| 1PLW | NMR | A=261-265 | |
| 1PLX | NMR | A=261-265 | |
| 2LWC | NMR | A=261-265 |
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