Beta-mammal toxin Cn2 is a 84-residue protein from Centruroides noxius. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01495.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2YC1 | X-ray | 1.9 Å | C/F=17-82 |
| 2YBR | X-ray | 2.55 Å | C/F/I=17-82 |
| 4V1D | X-ray | 3.1 Å | C=17-82 |
| 1CN2 | NMR | A=17-82 |
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