Apamin is a 46-residue protein from Apis mellifera. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01500.
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The mean pLDDT of this model is 71.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 54% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Toxin with unique selectivity to KCa2 channels (PubMed:10696100, PubMed:11212219, PubMed:11533126, PubMed:17142458, PubMed:20562108, PubMed:32560481, PubMed:36188602, PubMed:6122211, PubMed:9287325, PubMed:9459560). Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels (PubMed:10696100, PubMed:11212219, PubMed:11533126, PubMed:17142458, PubMed:20562108, PubMed:36188602, PubMed:9287325, PubMed:9459560). Does not show any antimicrobial activity (PubMed:36188602). In vivo, intracerebroventricular injection…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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