Delta-actitoxin-Avd2a is a 27-residue protein from Anemonia sulcata. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01535.
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The mean pLDDT of this model is 67.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 48% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Specific arthropod (crab and insect) toxin that inhibits inactivation of voltage-gated sodium channels. It competes well with the site-3 toxin LqhalphaIT (from the scorpion L.quinquestriatus (AC P17728)) on binding to cockroach neuronal membranes (Ki=21.4 nM), and inhibits the inactivation of D.melanogaster channel (DmNav1), but not that of mammalian Navs expressed in Xenopus oocytes. Its activity is synergically enhanced by ligands of receptor site-4 (Bj-xtrIT (AC P56637)). Its ability to inhibit the channel mutant DmNav1[D1701R] only decreases 5-fold, whereas the inhibition activity is completely lost by LqhalphaIT and Av2 when tested on DmNav1[D1701R]
Secreted, Nematocyst
Compare the prediction with experimentally determined structures of the same protein:
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