Histone H3.3C (h3-5) is a 136-residue protein from Xenopus laevis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02302.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1M19 | X-ray | 2.3 Å | A/E=2-136 |
| 6YN1 | X-ray | 2.35 Å | C/H/M/R/W/b/g/l=39-136 |
| 1M18 | X-ray | 2.45 Å | A/E=2-136 |
| 1M1A | X-ray | 2.65 Å | A/E=2-136 |
| 1AOI | X-ray | 2.8 Å | A/E=21-136 |
| 8TOF | EM | 2.8 Å | a/e=1-136 |
| 8EU2 | EM | 2.93 Å | K/O=39-136 |
| 8ETV | EM | 3.16 Å | A/E=1-136 |
| 8U5H | EM | 3.23 Å | I/O=1-136 |
| 6PX1 | EM | 3.3 Å | A/E=1-136 |
| 8DU4 | EM | 3.55 Å | A/E=1-136 |
| 7M1X | EM | 3.7 Å | A/E=1-136 |
| 6NZO | EM | 3.8 Å | A/E=1-136 |
| 6PX3 | EM | 4.1 Å | A/E=1-136 |
| 6FTX | EM | 4.5 Å | E=30-136 |
| 6FQ8 | EM | 4.8 Å | A/E=38-135 |
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